Belinda Brown  from Murdoch University in Perth Australia.
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Phone

9360 6193

Email

B.Brown@murdoch.edu.au

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    • Research
    • School

    Dr Belinda Brown
    BSc, PhD

    Research Fellow

    About me

    My research is primarily focused on understanding the role of lifestyle in maintaining a healthy ageing brain and preventing cognitive decline and dementia. My previous work has identified a role of physical activity in: reducing toxic brain proteins associated with Alzheimer’s disease, enhancing cognitive function, and maintaining brain volume. I currently hold an NHMRC-ARC Dementia Research Development Fellowship, in which I am building on my previous research to investigate the role of exercise intensity on cognitive function and brain MRI biomarkers.

    Current projects

    The Intense Physical Activity and Cognition (IPAC) study
    Co-CIs: Dr Jeremiah Peiffer
    This project is a 6 month exercise intervention, examining the effect of high-intensity exercise on cognitive function, brain MRI markers and relevant blood biomarkers.

    The Australian Imaging Biomarkers and Lifestyle (AIBL) study
    Led by: Prof Ralph Martins at Edith Cowan University and Prof Colin Masters and The University of Melbourne
    A large multi-disciplinary study of older adults aimed at identifying which biomarkers,cognitive characteristics and lifestyle factors determine subsequent development of symptomatic Alzheimer’s disease.

    The Western Australia Memory Study
    Led by: Dr Hamid Sohrabi, Prof Ralph Martins at Edith Cowan University
    An innovative study of ageing aimed at identifying links between ageing, psychological parameters and blood biomarkers.

     

    Awards and grants

    Brain Foundation Research Gift ($20,000) 2017
    The effect of high-intensity exercise on Alzheimer’s disease-related gene expression
    Chief Investigator: Belinda Brown
    Co-investigators: Simon Laws, Jeremiah Peiffer, Stephanie Rainey-Smith and Ralph Martins

    NHMRC/ARC National Institute of Dementia Dementia Research Development Fellowship ($600,079) 2016-2019
    The role of intense physical activity in protecting the ageing brain

    Alzheimer’s Australia Dementia Research Foundation
    Post-doctoral Research Fellowship ($110,000), 2014 – 2015
    The influence of exercise intensity on the prevention of cognitive decline in older adults

    Edith Cowan University Early Career Researcher Grant ($25,000) 2015
    Exercise intensity and cognition in the elderly

     Alzheimer’s Australia Dementia Research Foundation Rosemary Foundation Travel Grant ($15,000) 2015
    Travel to the Brain Aging and Cognitive Health Laboratory at the University of Pittsburgh

     

     

    Publications

    Journals

    • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, W., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Gardener, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, E., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C., (2018), Alzheimers disease: a journey from amyloid peptides and oxidative stress, to biomarker technologies and disease prevention strategies gains from AIBL and DIAN cohort studies, Journal of Alzheimer's Disease, 62, 3, pages 965 - 992.
    • Brown, B., Rainey-Smith, S., Dore, V., Peiffer, J., Burnham, S., Laws, S., Taddei, K., Ames, D., Masters, C., Rowe, C., Martins, R., Villemagne, V., (2018), Self-reported physical activity is associated with tau burden measured by positron emission tomography, Journal of Alzheimer's Disease, 63, 4, pages 1299 - 1305.
    • Weinborn, M., Bucks, R., Sohrabi, H., Rainey-Smith, S., Brown, B., Gardener, S., Gozt, A., Christensen, D., Savage, G., Laws, S., Taddei, K., Maruff, P., Robertson, J., Ellis, K., Ames, D., Masters, C., Rowe, C., Martins, R., (2018), Trajectories of Irregular Word Reading Ability as a Proxy for Premorbid Intelligence in Alzheimers Disease, Mild Cognitive Impairment and Healthy Aging: A Longitudinal Study, Psychological Assessment, 30, 10, pages 1308 - 1316.
    • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S., (2018), Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain A-amyloid burden, Translational Psychiatry, 8, 47, pages -.
    • Fernando, B., Rainey-Smith, S., Gardener, S., Villemagne, V., Burnham, S., Macaulay, S., Brown, B., Gupta, V., Sohrabi, H., Weinborn, M., Taddei, K., Laws, S., Goozee, K., Ames, D., Fowler, C., Maruff, P., Masters, C., Salvado, O., Rowe, C., Martins, R., (2018), Associations of dietary protein and fibre intake with brain and blood amyloid beta, Journal of Alzheimer's Disease, 61, 4, pages 1589 - 1598.
    • Brown, B., Rainey-Smith, S., Castalanelli, N., Gordon, N., Markovic, S., Sohrabi, H., Weinborn, M., Laws, S., Doecke, J., Shen, K., Martins, R., Peiffer, J., (2017), Study protocol of the Intense Physical Activity and Cognition (IPAC) study: The effect of high-intensity exercise training on cognitive function in older adults, Alzheimer's & Dementia: Translational Research & Clinical Interventions, 3, 4, pages 562 - 570.
    • Carlson-Hawke, P., Brown, B., Hammond, S., (2017), Anxiety and its Features in Parkinson's Disease, SM Journal of Neurology and Neuroscience, 3, 1, pages 1 - 5.
    • Brown, B., Sohrabi, H., Taddei, K., Gardener, S., Rainey-Smith, S., Peiffer, J., Xiong, C., Fagan, A., Benzinger, T., Buckles, V., Erickon, K., Clarnette, R., Shah, T., Masters, C., Weiner, M., Cairns, N., Rossor, M., Graff-Radford, N., Salloway, S., Voglein, J., Laske, C., Noble, J., Schofield, P., Bateman, R., Morris, J., Martins, R., (2017), Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimers disease, Alzheimer's & Dementia, 13, 11, pages 1197 - 1206.
    • Marston, K., Newton, M., Brown, B., Rainey-Smith, S., Bird, S., Martins, R., Peiffer, J., (2017), Intense resistance exercise increases peripheral brain-derived neurotrophic factor, Journal of Science and Medicine in Sport, 20, , pages 899 - 903.
    • Chatterjee, P., Lim, W., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R., (2016), Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study, Journal of Alzheimer's Disease, 50, 3, pages 887 - 894.
    • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R., (2015), Bone mineral density, adiposity, and cognitive functions, Frontiers in Aging Neuroscience, 7, 0, pages 0 - 0.
    • Brown, B., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Villemagne, V., Taddei, K., Bush, A., Ellis, A., Macaulay, S., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R., (2014), Influence of BDNF Val66Met on the relationship between physical activity and brain volume, Neurology, 83, 15, pages 1345 - 1352.
    • Brown, B., Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, S., Szoeke, C., Rowe, C., Martins, R., (2013), Physical activity and amyloid-beta plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing, Molecular Psychiatry, 18, 8, pages 875 - 881.
    • Brown, B., Peiffer, J., Martins, R., (2013), Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?, Molecular Psychiatry, 18, 8, pages 864 - 874.
    • Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, C., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, S., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R., (2012), Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease, Archives of Neurology, 69, 10, pages 1318 - 1325.
    • Brown, B., Peiffer, J., Sohrabi, H., Mondal, A., Gupta, V., Rainey-Smith, S., Taddei, K., Burnham, S., Ellis, K., Szoeke, C., Masters, C., Ames, D., Rowe, C., Martins, R., (2012), Intense physical activity is associated with cognitive performance in the elderly, Translational Psychiatry, 2, 2012, pages e191 -.