Dr Belinda Brown
BSc, PhD

Research Fellow

About me

My research is primarily focused on understanding the role of lifestyle in maintaining a healthy ageing brain and preventing cognitive decline and dementia. My previous work has identified a role of physical activity in: reducing toxic brain proteins associated with Alzheimer’s disease, enhancing cognitive function, and maintaining brain volume. I currently hold an NHMRC-ARC Dementia Research Development Fellowship, in which I am building on my previous research to investigate the role of exercise intensity on cognitive function and brain MRI biomarkers.

Current projects

The Intense Physical Activity and Cognition (IPAC) study
Co-CIs: Dr Jeremiah Peiffer
This project is a 6 month exercise intervention, examining the effect of high-intensity exercise on cognitive function, brain MRI markers and relevant blood biomarkers.

The Australian Imaging Biomarkers and Lifestyle (AIBL) study
Led by: Prof Ralph Martins at Edith Cowan University and Prof Colin Masters and The University of Melbourne
A large multi-disciplinary study of older adults aimed at identifying which biomarkers,cognitive characteristics and lifestyle factors determine subsequent development of symptomatic Alzheimer’s disease.

The Western Australia Memory Study
Led by: Dr Hamid Sohrabi, Prof Ralph Martins at Edith Cowan University
An innovative study of ageing aimed at identifying links between ageing, psychological parameters and blood biomarkers.

 

Awards and grants

Brain Foundation Research Gift ($20,000) 2017
The effect of high-intensity exercise on Alzheimer’s disease-related gene expression
Chief Investigator: Belinda Brown
Co-investigators: Simon Laws, Jeremiah Peiffer, Stephanie Rainey-Smith and Ralph Martins

NHMRC/ARC National Institute of Dementia Dementia Research Development Fellowship ($600,079) 2016-2019
The role of intense physical activity in protecting the ageing brain

Alzheimer’s Australia Dementia Research Foundation
Post-doctoral Research Fellowship ($110,000), 2014 – 2015
The influence of exercise intensity on the prevention of cognitive decline in older adults

Edith Cowan University Early Career Researcher Grant ($25,000) 2015
Exercise intensity and cognition in the elderly

 Alzheimer’s Australia Dementia Research Foundation Rosemary Foundation Travel Grant ($15,000) 2015
Travel to the Brain Aging and Cognitive Health Laboratory at the University of Pittsburgh

 

 

Publications

Journals

  • Chatterjee, P., Lim, W., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R., (2016), Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study, Journal of Alzheimer's Disease, 50, 3, pages 887 - 894.
  • Brown, B., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Villemagne, V., Taddei, K., Bush, A., Ellis, A., Macaulay, S., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R., (2014), Influence of BDNF Val66Met on the relationship between physical activity and brain volume, Neurology, 83, 15, pages 1345 - 1352.
  • Brown, B., Peiffer, J., Martins, R., (2013), Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?, Molecular Psychiatry, 18, 8, pages 864 - 874.
  • Brown, B., Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, S., Szoeke, C., Rowe, C., Martins, R., (2012), Physical activity and amyloid- plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing, Molecular Psychiatry, 18, 8, pages 875 - 881.
  • Brown, B., Peiffer, J., Sohrabi, H., Mondal, A., Gupta, V., Rainey-Smith, S., Taddei, K., Burnham, S., Ellis, K., Szoeke, C., Masters, C., Ames, D., Rowe, C., Martins, R., (2012), Intense physical activity is associated with cognitive performance in the elderly, Translational Research: the journal of laboratory and clinical medicine, 2, , pages -.
  • Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, C., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, S., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R., (2012), Blood-Based Protein Biomarkers for Diagnosis of Alzheimer's disease, Archives of Neurology, 69, 10, pages 1318 - 1325.