Associate Professor Murray Adams
BSc(Hons), PhD, MAIMS, FFSc(RCPA)

Associate Professor in Haematology

About me

Background

I am an Associate Professor in Haematology and Academic Chair of Laboratory Medicine in the School of Veterinary and Life Sciences. I completed my B.Sc (Medical Science) in 1992 and B.Sc with First Class Honours in 1993, both at Curtin University of Technology. After working as medical scientist in the Department of Laboratory Services at Royal Perth Hospital and completing a PhD at Curtin in 1999, I worked as a Research Fellow in the laboratory of Prof Sam Machin and Dr Ian Mackie in the Haemostasis Research Unit, University College London. Upon returning to Curtin, I was appointed Lecturer in Clinical Sciences, and later moved to the University of Tasmania in 2007 as Senior Lecturer in Haematology and Course Coordinator of the Bachelor of Biomedical Science.

I have taught both undergraduate and postgraduate haematology (including general and malignant haematology, thrombosis and haemostasis, and transfusion science) to science and medical students and have a particular interest in case study-based teaching. My research interests cover a broad range of topics across haematology, thrombosis and haemostasis, and cell biology. Current research projects include investigating the interactions between platelets and antiphospholipid antibodies, the action of vanilloid-like agents on platelet function, the impact of travel and exercise on haemostasis, as well as investigating abnormalities of the tissue factor pathway of blood coagulation.

 

Certifications

Member, Australian Institute of Medical Scientists [MAIMS]

Accredited through Australian Professional Acknowledgement Continuing Education (APACE) 

Fellow, Faculty of Science, Royal College of Pathologists Australasia [FFSc (RCPA)]

 

Professional Memberships (Current)

Thrombosis and Haemostasis Society of Australia and New Zealand (THANZ)

Australian Institute of Medical Scientists (AIMS)

International Society of Thrombosis and Haemostasis (ISTH)

Royal College of Pathologists Australasia (RCPA)

Asia-Pacific Society of Thrombosis and Haemostasis (APSTH)

 

Teaching area

Unit Coordinator:

BMS431 Laboratory Medicine Practice 1 

BMS432 Laboratory Medicine Practice 2 

BMS426 Clinical Haematology 2 

BMS326 Clinical Haematology 1

Other Teaching:

BMS315 Advances in Medical Science

BMS218 Haematology

Research areas

I am interested in the body’s haemostatic system, the mechanism that ensures excessive clotting or bleeding does not occur.

Specific research interests include the investigation of haemostatic abnormalities that contribute to the development of blood clots (thrombosis). Blood clots can develop in people with a range of diseases including cardiovascular diseases, cancer, diabetes, kidney disease and a range of autoimmune conditions, including systemic lupus erythematosus (SLE or ‘lupus’) and the antiphospholipid syndrome (APS). They are a leading cause of illness and deaths, particularly in developed countries with aging populations, and impact significantly on healthcare systems.

The following haemostasis based projects are ongoing,

  1. The effects of pathological antibodies found in patients with autoimmune diseases (particularly SLE and APS) on platelets, blood coagulation and fibrinolysis.
  2. Novel biomarkers in patients with autoimmune diseases that are associated with the development of blood clots and their association with inflammation.
  3. Natural compounds found in hot chilli peppers and their effects on platelet function, particularly those mediated through the ‘chili-receptor’, transient potential vanilloid-1 (TRPV1).
  4. The effects of exercise, high intensity training, and travel, on haemostasis.

Current collaborators include;

  • Prof Ross Baker, Dr Jasmine Tay, Dr Quintin Hughes and Dr Jim Tiao at the Western Australian Centre for Thrombosis and Haemostasis (WACTH) at Murdoch University.
  • Dr Kiran Ahuja and Prof Dom Geraghty in the School of Health Sciences at the University of Tasmania.
  • A/Prof James Fell and colleagues in the Sports Performance Optimisation Research Team (SPORT) at the University of Tasmania.
  • Prof Heinrich Korner at the Menzies Institute for Medical Research, University of Tasmania.
  • A/Prof Robert Andrews at the Australian Centre for Blood Diseases, Monash University.
  • Dr Paul Ellery in the School of Biomedical Sciences, Curtin University.

 

Doctoral and masters supervisions

I have supervised 10 PhD and Masters by Research candidates to completion as well as 20 Honours candidates. I am currently supervising 3 PhD and 1 Honours candidates with their projects having a haemostasis focus or component.Students who are interested in working on haemostasis based projects should contact me via M.Adams@murdoch.edu.au, including a detailed CV, as well as a description of the type of research that they would like to undertake. Potential HDR students should have a relevant Bachelor’s degree (with Honours), or Masters by Research degree, with peer-reviewed publications.

 

Publications

Chapters

  • Omari, S., Adams, M., Geraghty, D., (2017),TRPV1 Channels in Immune Cells and Hematological Malignancies,In: Advances in pharmacology, Academic Press (Elsevier), pages 173 to 198.

Journals

  • Zadow, E., Kitic, C., Wu, S., Fell, J., Adams, M., (2018), Time of day and short-duration high-intensity exercise influences on coagulation and fibrinolysis, European Journal of Sport Science, 18, 3, pages 367 - 375.
  • Almaghrabi, S., Adams, M., Geraghty, D., Ahuja, K., (2018), Synergistic inhibitory effect of capsaicin anddihydrocapsaicin on in-vitro platelet aggregationand thromboxane formation, Blood Coagulation and Fibrinolysis, 29, 4, pages -.
  • Ho, Y., Ahuja, K., Adams, M., (2017), Further Investigations of the Effects of Anti-2GP1 Antibodies on Collagen-Induced Platelet Aggregation, Clinical and Applied Thrombosis/Hemostasis, , , pages 1 - 6.
  • Lee, A., Bannan, J., Adams, M., Korner, H., (2017), Expression of CCR6 on B cells in systemic lupus erythematosus patients, Clinical Rheumatology, 36, 6, pages 1453 - 1456.
  • Ho YC, Ahuja KDK, Körner H, and Adams MJ. β2GP1, Anti-β2GP1 antibodies and platelets: Key players in the antiphospholipid syndrome. Antibodies. 5, 12. 2016.
  • Nikolic SB, Edwards LM, Karpievitch YV, Wilson R, Horne J, Adams MJ, Sharman JE. Serum metabolomic profile predicts adverse haemodynamics in patients with type 2 diabetes mellitus. Acta Diabetologica. 53, 367-375. 2016.
  • Almaghrabi SY, Geraghty DP, Ahuja KDK, Adams MJ. Inhibition of platelet aggregation by vanilloid-like agents is not mediated by transient receptor potential vanilloid-1 channels or cannabinoid receptors. Clinical and Experimental Pharmacology and Physiology. 43, 606-611. 2016.
  • Omari SA, Adams MJ, Kunde DA, Geraghty DP. Capsaicin-induced death of human haematological malignant cell lines is independent of TRPV1 activation. Pharmacology. 98, 79-86. 2016.
  • Dhillon PK, Khalafallah AA, Adams MJ. Changes to fibrinolysis in patients with systemic lupus erythematosus are associated with endothelial cell damage and inflammation, but not antiphospholipid antibodies. Blood Coagulation and Fibrinolysis. 27, 870-875. 2016.
  • Almaghrabi SY, Geraghty DP, Ahuja KDK, Adams MJ. Vanilloid-like agents inhibit aggregation of human platelets. Thrombosis Research. 134, 412-417. 2014.
  • Nikolic SB, Adams MJ, Otahal P, Edwards LM, Sharman JE. Association of von Willebrand factor blood levels with exercise hypertension. European Journal of Applied Physiology. 115, 1057-1065. 2015.
  • Ellery PER, Adams MJ. Tissue factor pathway inhibitor: Then and Now. Seminars in Thrombosis and Hemostasis. 40, 881-886. 2014.
  • Nikolic S, Wilson R, Hare J, Adams MJ, Edwards L, Sharman J. Spironlactone reduces aortic stiffness via the blood pressure-dependent effects of canrenoate. Metabolomics. 10, 105-113, 2014.
  • Pirie AD, Davies NW, Ahuja KDK, Adams MJ, Shing CM, Narkowicz C, Jacobson GA, Geraghty DP. A crude extract from Carpobrotus rossii (pigface) lowers cholesterol in healthy rats. Food and Chemical Toxicology. 66, 134-139. 2014.
  • Nikolic S, Sharman J, Adams MJ, Wilson R. Metabolomics in hypertension. Journal of Hypertension. 32, 1159-1169. 2014.
  • Adams MJ, Almaghrabi S, Ahuja KDK, Geraghty DP. Vanilloid like agents: potential therapeutic targeting of platelets? Drug Development Research. 74, 450-459, 2013.
  • Dhillon PK, Adams MJ. Thrombosis in SLE: The role of impaired fibrinolysis. Seminars in Thrombosis and Hemostasis. 39, 434-440. 2013.
  • King SG, Ahuja KDK, Kay J, Shing CM, Adams MJ, Davies JE, Sharman JE, Williams AD. Effect of whole-body mild-cold exposure on central hemodynamics: A randomized, cross-over trial. European Journal of Applied Physiology. 113, 1257-1269, 2013.
  • Adams MJ. Measurement of lupus anticoagulants: An update on quality in laboratory testing. Seminars in Thrombosis and Hemostasis. 39, 267-271, 2013.
  • Betts NA, Ahuja KDK, Adams MJ. Human and rabbit anti-β2GP1 antibodies have variable effects on platelet aggregation. Pathology. 45, 155-161. 2013.
  • Palatinus AA, Ahuja KDK, and Adams MJ. Effect of APL on in vitro platelet aggregation. Clinical and Applied Thrombosis and Hemostasis. 18, 60 – 66, 2012.
  • Adams MJ. Tissue factor pathway inhibitor: New insights into an old inhibitor. Seminars in Thrombosis and Hemostasis. 38, 129 – 134, 2012.
  • Ahuja KDK, Thomas G, Adams MJ, and Ball MJ. Postprandial platelet aggregation: effects of different meals and glycemic index. European Journal of Clinical Nutrition. 66, 722 – 726, 2012.
  • Khalafallah AA, Morse M, Dennis A, Adams MJ, Bates G, Robertson I, Seaton D and Brain T. D-Dimer levels at different stages of pregnancy in australian women: a single centre study using two different immunoturbidometric assays. Thrombosis Research. 130, e171-177, 2012.
  • Shing CM, Adams MJ, Coombs J, and Fassett R. Nutritional supplements influence inflammatory markers and tissue factor in chronic kidney disease. Nutrition 27, 967-972. 2011.
  • GeraghtyDP, Ahuja KDK, Pittaway J, Shing CM, Jacobson GA, Jager N, Jurkovic S, Narkowicz C, Ball MJ, Pinkard A, Vennavaram RR, and Adams MJ. In vitro antioxidant, antiplatelet and potential anti-inflammatory activity of Carpobrotus rossii (pigface) extract. Journal of Ethnopharmacology. 134, 97-103, 2011.
  • Adams MJ, Palatinus AA, Harvey AM, and Khalafallah AA. Impaired control of the tissue factor pathway of blood coagulation in systemic lupus erythematosus. Lupus. 20, 1476 – 1485, 2011.
  • Adams MJ. Assessment of thrombin generation. European Haematology (now European Oncology and Haematology). 4, 16-18, 2010.
  • Adams MJ. Assessment of thrombin generation: useful or hype? Seminars in Thrombosis and Hemostasis. 35, 104-110. 2009.
  • Adams MJ, Williams A, Fell J. Exercise in the fight against thrombosis: friend or foe?  Seminars in Thrombosis and Hemostasis. 35, 261-268. 2009.
  • Pearson L, Thom J, Adams MJ, Oostryck R, Krueger R, Yong G, and Baker R. A rapid flow cytometric technique for the detection of platelet-monocyte complexes, activated platelets and platelet-derived microparticles. International Journal of Laboratory Haematology. 31, 430-439. 2009.
  • Ahuja KDK, Adams MJ, Robertson I and Ball MJ. Acute effect of a high-carbohydrate low-fat meal on platelet aggregation. Platelets, 20, 606-609. 2009.
  • Adams MJ, Ahuja KDK and Geraghty DP. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thrombosis Research. 124, 721-723. 2009.
  • Adams MJ, Williams A and Fell J. Exercise causing thrombosis? The Physician and Sportsmedicine. 37, 124-130, 2009.
  • Palatinus, AA and Adams MJ. Thrombosis in systemic lupus erythematosus.  Seminars in Thrombosis and Hemostasis. 35, 621-629. 2009.
  • Ellery PER, Hardy K, Oostryck R and Adams MJ. Further insight into the heparin-releasable and glycosylphosphatidylinositol-lipid anchored forms of tissue factor pathway inhibitor. Clinical and Applied Thrombosis and Haemostasis. 14, 267-278. 2008.
  • Adams MJ. Novel considerations in the pathogenesis of the antiphospholipid syndrome: involvement of the tissue factor pathway of blood coagulation. Seminars in Thrombosis and Hemostasis. 34, 251-255. 2008.
  • Adams MJ, Irish AB, Watts GF, Oostryck R and Dogra GK.  Hypercoagulability in chronic kidney disease is associated with coagulation activation but not endothelial function. Thrombosis Research. 123, 374-380. 2008.
  • Adams MJ, Ward C, Thom J, Bianchi A, Perrin E, Coghlan D and Smith M. Emerging technologies in hemostasis diagnostics: a report from the Australasian Society for Thrombosis and Haemostasis Emerging Technologies Group. Seminars in Thrombosis and Haemostasis. 33, 226-234, 2007.
  • Lean SY and Adams MJ. A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome. Australian Journal of Medical Science. 28, 99-107. 2007.
  • Lincz LF, Adams MJ,Scorgie, FE, Thom J, Baker RI and Seldon M. Polymorphisms of the tissue factor pathway inhibitor gene predict risk of thrombosis in patients predisposed to hypercoaguability. Blood Coagulation and Fibrinolysis. 18, 559-564, 2007.
  • Sayer MS, Cole VJ, Adams MJ, Baker RI and Staton JM. Polymorphisms in the TFPI gene are not associated with ischaemic stroke. Blood Coagulation and Fibrinolysis. 18, 703-8. 2007.
  • Adams MJ, Thom J, Hankey GJ, Baker RI, Gilmore G, Staton J, Yi Q and Eikelboom, JW. The tissue factor pathway in ischemic stroke. Blood Coagulation and Fibrinolysis.  17, 527-532. 2006.
  • Lean SY, Ellery PE, Ivey L, Thom J, Oostryck R, Leahy M, Baker RI and Adams MJ. The effects of tissue factor pathway inhibitor and anti-ß2-glycoprotein-I IgG on thrombin generation. Haematologica.  91, 1360-1366, 2006
  • Adams MJ, Breckler L, Stevens P, Thom J, Baker RI and Oostryck R. Anti-TFPI activity in subjects with the antiphospholipid syndrome is associated with increased thrombin generation. Haematologica. 89, 985-990, 2004.
  • Adams MJ, Cardigan RA, Marchant WA, Grocott MPW, Mythen M, Mutch M, Purdy G, Mackie IJ and Machin SJ. Tissue factor pathway inhibitor antigen and activity in 96 patients undergoing cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia. 16, 59-63, 2002.
  • Adams MJ, Donohoe S, Mackie IJ and Machin SJ.  Anti-TFPI activity in patients with the primary antiphospholipid syndrome. British Journal of Haematology. 114, 375-379, 2001.
  • Adams MJ and Oostryck R. A comparative study of functional assays for tissue factor pathway inhibitor using normal plasma and clinical samples.  Blood Coagulation and Fibrinolysis. 11, 327-333. 2000.
  • Adams MJ and Oostryck R. Tissue factor pathway inhibitor: Regulator of the tissue factor pathway of coagulation and a future antithrombotic agent? Australian Journal of Medical Science. 21, 2-9. 2000.
  • Dimmitt SB, Rakic V, Puddey IB, Baker, R, Adams MJ, Oostryck R, Chesterton CN, Burke V and Beilin LJ. The effects of alcohol on coagulation and fibrinolytic factors: a controlled intervention study. Blood Coagulation and Fibrinolysis. 9, 39-45. 1998.
  • Adams MJ and Oostryck, R. Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor. Thrombosis Research. 87, 245-249. 1997.
  • Adams MJ, Dunstan RA and Oostryck, R. Interference by lupus anticoagulant in a functional assay for tissue factor pathway inhibitor. Thrombosis Research. 80, 435-440, 1995.